Bergqvist D, Ljungner H, Nilsson M.
Venous emptying from the calf. Methodologic report and effect of intermittent
pneumatic compression.
Acta Chir Scand 1982;148(8);669-73

In 17 patients undergoing surgery for varicose veins of the leg, the elimination
rate of 99Tcm-macroaggregated albumin from the calf of the contralateral leg was
studied. The leg had no discernible varicosities. This substance has not previously
been used in such a context. Its theoretical advantages are discussed. A
mathematical method for interpreting the elimination rate is presented. Two modes
of intermittent calf compression--a slow and a fast pattern--were compared, and
also control group without compression. The elimination rate of the radioisotope
was slower with compression than without. Possible interpretations and
implications of this observation are discussed.